The aim of this paper is to investigate the effect of knowledge (general knowledge on COVID-19 and transmission knowledge on COVID-19) and attitudes towards prevention and control of COVID-19 contamination. In this study, an online survey approach was used, and primary data were collected through structured questionnaire from 410 respondents’ who actively participated in the survey. This study is conducted based on Theory of Planned Behavior (TPB). Five (5) research hypotheses were constructed in order to fulfill the objective of this study. The proposed research hypotheses were tested by using PLS-SEM techniques. The results showed that entirely all five hypotheses were accepted. Precisely, general knowledge on COVID-19, transmission knowledge on COVID-19 and attitudes towards prevention & control positively contributes to the behavior towards prevention and control of COVID-19 infection. Furthermore, the findings suggest that proper knowledge and optimistic attitudes on COVID-19 may change the behavioral pattern of people to prevent and control the COVID-19 infection. The outcomes of this study are significant to convey future efforts to focus on social preparation to conform the pandemic control measures. One of the significant drawbacks of this study is that the data was collected through online questionnaire survey and during pandemic.